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Lactobacillus from the Altered Schaedler Flora maintain IFNγ homeostasis to promote behavioral stress resilience
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Association of pathological and volumetric biomarker changes with cognitive decline in clinically normal adults: Harvard Aging Brain Study
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Synaptic proteasome is inhibited in Alzheimer’s disease models and associates with memory impairment in mice
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Chronic GCPII (glutamate-carboxypeptidase-II) inhibition reduces pT217Tau levels in the entorhinal and dorsolateral prefrontal cortices of aged macaques
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Microbiota from Alzheimer’s patients induce deficits in cognition and hippocampal neurogenesis
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Direct neuronal conversion of microglia/macrophages reinstates neurological function after stroke
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Neuronal activity drives IGF2 expression from pericytes to form long-term memory
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Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion
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The Q/R editing site of AMPA receptor GluA2 subunit acts as an epigenetic switch regulating dendritic spines, neurodegeneration and cognitive deficits in Alzheimer’s disease
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Long non-coding RNA SNHG8 drives stress granule formation in tauopathies
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MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer’s disease
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Evidence supportive of a bacterial component in the etiology for Alzheimer’s disease and for a temporal-spatial development of a pathogenic microbiome in the brain
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The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis
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Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s diseas
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Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
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Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1
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Transient anxiety-and depression-like behaviors are linked to the depletion of Foxp3-expressing cells via inflammasome in the brain
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Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice